The role of the non-coding genome in epilepsy has primarily been focused on the widespread disruption of microRNA (miRNA) expression and function [1]. However, the involvement of long non-coding RNAs (lncRNAs) in epilepsy remains unknown. LncRNAs are a heterogeneous group of non-coding transcripts (longer than 200 nt) that play roles in many biological processes [2] and comprise the largest portion of the mammalian non-coding transcriptome. LncRNAs are involved in many transcriptional regulatory processes [3]; for example, lncRNAs mediate the efficiency of upstream promoter region transcription of protein-coding genes and disrupt the downstream expression of genes, such as the SER3 gene in yeast [4].

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