SCN1A-related disorders include Dravet syndrome (DS), genetic epilepsy with febrile seizures plus (GEFS+), and familial hemiplegic migraine as the main phenotypes [1]. However, a novel phenotype with early onset epileptic encephalopathy, profound developmental delay and an hyperkinetic movement disorder has been recently described, mainly in association with the missense mutation p.Thr226Met [2].

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