Alzheimer’s disease (AD; MIM#104300) is the most common form of neurodegenerative disorder occurring predominantly in later life with complex etiology and a strong genetic component [1]. AD is a devastating progressive disease characterized by memory loss, confusion, thinking difficulty and changes in behavior, personality and language. The definitive diagnosis of AD is only possible by post-mortem histopathology examination of the intraneuronal presence of neurofibrillary tangles (NFTs), composed of highly phosphorylated forms of the microtubule-associated protein tau, and plaques constituted by the amyloid-β (Aβ) peptide.

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