Epilepsy is one of the most common neurological diseases. Up to 30% of patients ultimately develop refractory epilepsy despite appropriate medical therapy [1]. In recent years, a number of newer AEDs with more desirable safety profiles have been introduced on the market to offer better seizure control for patients with epilepsy, especially for those with refractory epilepsy. Consequently, add-on therapy with newer AEDs is now considered an important choice for patients with refractory epilepsy [2].

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