Several antiepileptic drugs (AEDs) have been discovered by happenstance, often uncovering their efficacy in the course of use for other indications. Phenobarbital, originally introduced as a hypnotic, was used by Alfred Hauptmann in 1912 in an effort to help his patients with epilepsy get a better night’s sleep. Seizure incidence and intensity were reduced leading him to ascribe anti-seizure properties to the drug [1]. Valproic acid’s (VPA) anticonvulsant properties were fortuitously discovered in 1962 by Pierre Eymard and colleagues who used VPA as a solvent to dissolve other water-insoluble compounds.

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