admin May 15, 2019

Recent tau Positron Emission Tomography (PET) allows assessment of regional neurofibrillary tangles deposition in human brain. 18F-AV1451 is characterized by high selectivity for pathologic tau aggregates. The objectives of the study are 1) to quantitatively characterize regional brain tau deposition measured by 18F-AV1451 PET in cognitively normal older adults (CN), mild cognitive impairment (MCI) and AD participants; 2) to evaluate the correlations between CSF biomarkers or Mini-Mental State Examination (MMSE) and standardized uptake value ratio (SUVR); and 3) to evaluate the partial volume effects on 18F-AV1451 brain uptake. Methods: The study included total 115 participants (CN=49, MCI=58 and AD=8) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Preprocessed 18F-AV1451 PET images, structural MRIs, and demographic and clinical assessments were downloaded from the ADNI database. Voxelwise partial volume correction (PVC) on PET images was introduced. PVC and non-PVC SUVR images were compared. The correlation between SUVR and MMSE, CSF total tau (t-tau) and phosphorylated tau (p-tau) were also assessed. Results: 18F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal and frontal brain regions. Most SUVRs showed significantly higher uptake of 18F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in groups (p0.05). Declined MMSE score was observed with increasing 18F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus and fusiform. CSF p-tau was positively correlated with 18F-AV1451 deposition. Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and they were strongly associated with cognitive impairment and CSF biomarkers. 18F-AV-1451 PET imaging could not differentiate the MCI from CN population. More tau deposition related to decreased MMSE score and increased CSF p-tau level . PVC improved the results of tau deposition and correlation studies in small brain regions and suggested to be routinely used in 18F-AV1451 tau PET quantification.

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