How Wnt signaling coordinates vascular remodeling and barrier maturation in the retina is poorly understood. Mazzoni et al. demonstrate that mice lacking Apcdd1 exhibit decreased vessel pruning and precocious formation of the blood-retina barrier. Conversely, Apcdd1 overexpression in endothelial cells induces the opposite phenotype. Apcdd1 precisely sculpts Wnt activity to coordinate vascular pruning and barrier maturation.

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