Assembly of the NLRP3 inflammasome leads to caspase-1 activation and mediates the cleaving and release of several inflammatory cytokines. The NLRP3 inflammasome can amplify inflammatory responses and thus worsen several diseases. Duchenne muscular dystrophy (DMD) is one of the most devastating muscle disease and it is known to harbour a severe inflammation. We have recently shown that NLRP3 was more expressed in skeletal muscle fibers of mdx mice (a murine model of DMD) than in Wild-Type (WT) mice.

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