Lipodystrophies are a heterogeneous group of disorders characterized by congenital or acquired loss of adipose tissue [1]. The loss of adipose tissue is associated with insulin resistance in patients with lipodystrophy [2]. The body fat is almost totally absent in patients with generalized lipodystrophy. Several genes have been identified for congenital generalized lipodystrophy (CGL), which are 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2, CGL1) [3], Berardinelli–Seip congenital lipodystrophy 2 (BSCL2, CGL2) [4], caveolin 1 (CAV1, CGL3) [5] and polymerase I and transcript release factor (PTRF, CGL4) [6,7], all of which are inherited as autosomal recessive traits.

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