The congenital disorders of glycosylation (CDG) are a group of clinically and biochemically heterogeneous diseases characterized by multisystem involvement due to glycosylation defect of protein and lipid [1, 2]. The protein glycosylation in human cells is classified into N- and O-linked glycosylation [3]. Phosphoglucomutase type 1 (PGM1) is the predominant isoform of PGM in skeletal muscle and most other tissues, which is critical for catalyzing the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), as well as glycogenesis and glycogenolysis [4, 5].

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