Primary inflammatory/dysimmune myopathies (PIDM) include (i) polymyositis (PM)/inclusion body myositis (IBM), (ii) dermatomyositis (DM), (iii) necrotizing autoimmune myopathy, and (iv) overlap myositis (OM) . Type I α/β interferon signature was proposed as a characteristic feature of DM . Since OM and IBM differ from other PIDM by the presence of major histocompatibility complex (MHC)-2 expression by myofibers, we hypothesized that they are characterized by interferon (IFN)γ-mediated inflammation.

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