Muscle satellite cell is muscle progenitor cell, which generates myoblast to repair wounded skeletal myofiber. Regeneration occurs efficiently with help of muscle-resident mesenchymal progenitor cells. In last-this meeting, we showed transplantation of bone marrow-derived mesenchymal stromal cells (Bm-MSCs) also facilitated muscle regeneration in Duchenne muscular dystrophy (DMD) model mice, which lead to drastic efficacy against death-related symptoms. Moreover, we showed the efficacy was attributed to chemokine CXCL12 and osteopontin (OPN) secreted from Bm-MSCs, which affected on self-renew of muscle satellite cell and myoblast fusion in muscle regeneration, respectively.

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