Statistically significant differences in clinical trial outcome measures do not always translate into relevant or meaningful differences for patients and their families. Minimal clinical important difference (MCID) is defined as the smallest change that is considered meaningful by patients, parents and/or clinicians. It can be determined using statistical or qualitative methods or often a combination of the two. As therapeutic advances in the treatment of Duchenne muscular dystrophy (DMD) progress, there is a pressing need to determine the MCID for Clinical trial endpoints.

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