NMR imaging, and particularly T1-weighted acquisitions, can be used for the diagnostic of NMDs taking advantage of the high contrast between healthy and fatty infiltrated muscles. However, very little is known about the effects of tissue water compartmentation and distribution on muscle T1 values. With the development of fast T1 mapping sequences, it is now possible to monitor this parameter within scan times compatible with clinical research. The goal of this study was to investigate the variations of skeletal muscle T1 values under various physiopathological conditions using a fast T1 mapping sequence.

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