Sporadic inclusion body myositis (sIBM) is the most frequent acquired inflammatory myopathy in patients older than 50 years of age. Deficit in protein degradation and mitochondrial function has been suggested to be involved in pathogenesis of sIBM. Although, autoantibodies recognizing cytosolic 5′-Nucleotidase 1A (cN1A) were found in the sera of patients with sIBM, role of the autoantibodies remains unclear. In the current study, we established novel in vivo and in vitro models to analyze the effect of the autoantibodies on myodegeneration.

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