We describe changes in pulmonary function measures across time in Duchenne muscular dystrophy (DMD) patients treated with glucocorticoids (GC) > 1 year compared to steroid naïve patients in a large multi-center prospective natural history study. In the Cooperative International Research Group (CINRG) Duchenne Natural History Study (DNHS), 397 participants underwent 2799 pulmonary function assessments (PFT) and Brooke Scale of Upper Extremity Function over a period < 1 year to 10 years. Fifty-three GC naïve participants (<1 month GC exposure) were compared to 322 subjects with > 1 year cumulative GC treatment.

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