Riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency (RR-MADD) is an inherited fatty acid metabolism disorder mainly caused by genetic defects in electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO). This disease was reported to be more common in Chinese population accounting for 3-5% of muscle biopsies from several neuromuscular centers in China. The variant ETF-QO protein folding deficiency, which can be corrected by therapeutic dosage riboflavin supplement, has been identified in HEK-293 cells and is believed to be the molecular mechanism of this disease.

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