P. Mishra September 6, 2018

Besides their critical role in bioenergetics, mitochondria additionally display complex dynamic behaviors within cells, including fusion, fission, directed transport and targeted destruction (mitophagy). The relevance of these processes to human disease has been intensively documented over the last several years. While oxidative phosphorylation defects are classically associated with muscular dysfunction, more recent work indicates that genetic defects in mitochondrial dynamics are also associated with myopathy in mice and humans.


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