Efforts to treat Duchenne muscular dystrophy (DMD) mainly focus on strategies aimed at increasing dystrophin expression, or enhancing muscle regeneration/growth. However, the process of cell death in muscle wasting disorders has been largely overlooked. In DMD, fibres die with a necrotic morphology, making myonecrosis a central process in its pathogenesis. Inflammation and oxidative stress play a significant part in muscle loss, but how inflammation induces myonecrosis is still unknown. Lately, there has been a conceptual revolution in the cell death field, with the discovery of regulated forms of necrosis.

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