Titin, encoded by the 364-exon TTN gene [OMIM #188840], is the largest protein in nature [1]. It acts as one of the main sarcomere components, each titin molecule bridges half of the entire sarcomere to form a continuous elastic myofilament. These myofilaments provide a scaffold for sarcomere assembly during muscle development, maintain sarcomeric structural integrity, generate passive tension, and serve as key mechanosensing and signaling hubs [2,3].

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