A recent publication in your journal reported the identification of a genetic modifier, microRNA149 (MIR149), of Charcot-Marie-Tooth disease type 1A (CMT1A) [1]. In a sample of Korean patients, Nam et al. demonstrated significant association of the common SNP rs2292832 in MIR149 with age at onset (AAO) and severity of CMT1A. They also noted that the varying minor allele frequency (MAF) of rs2292832 in ancestral groups: the frequency of the C allele is 0.363 in East Asians, 0.718 in Europeans, and 0.728 in Africans [2].

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