Despite intense efforts, no cure is currently available for Duchenne muscular dystrophy and glucocorticoids are the only drug effective for slowing disease progression. In skeletyal muscle, estrogens have been proven to stimulate growth and regeneration and reduce inflammation and fibrosis. We have used young mdx mice to demonstrate that short-term estradiol administration caused a notable decrease in CK levels and improved motor function. Aiming to decipher the mechanisms of action of estradiol, we analyzed differentially expressed genes in the muscle of mdx mice treated either with estradiol or placebo for 4 weeks, and identified the low-affinity receptor for neurotrophins p75NTR as one of the most upregulated genes.

Read More...

Leave a comment.

Your email address will not be published. Required fields are marked*

Andoird App
Loading...