Diffusion tensor imaging (DTI) is an MRI technique that aims to probe muscle architecture. The technique could be relevant in neuromuscular disorders (NMDs) where differences in fiber size and increased membrane permeability occur. Two approaches are relevant, spin-echo (SE-)DTI and stimulated-echo (STE-)DTI. While STE-DTI has a lower signal to noise ratio (SNR), it allows probing of the long diffusion distances present in skeletal muscle, which SE-DTI cannot. STE-DTI may thus be more sensitive, but has not been applied in NMD, as fat reduces the amount of water signal per voxel, and thus water SNR.

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