Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of inherited peripheral neuropathies affecting 3 to 82 per 100,000 individuals of both sexes and all backgrounds [1]. CMT is characterised by demyelination and/or axonal degeneration of the peripheral nerves, with typical onset in the first two decades of life [2,3]. More than 90 causative genes have been identified so far, and CMT type 1A is the most common subtype [4]. Most patients exhibit a length-dependent progression of symptoms and impairments, with symptoms initially distal at the feet and hands, progressing proximally.

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