Taurine (Tau) is the most abundant free amino acid in heart and skeletal muscle. In these tissues Tau is involved in normal contractile function by regulating the calcium homeostasis and the calcium sensitivity of the contractile proteins. Preclinical studies in mdx mice disclosed promising effects of Tau as a countermeasure for the early alterations of skeletal muscle in Duchenne muscular dystrophy (DMD). DMD is a rare disease caused by the absence of sub-sarcolemmal protein dystrophin, progressively leading to skeletal muscle wasting and heart failure via altered calcium homeostasis abnormal inflammation and profibrotic signaling.

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