Hideyuki Kano September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVE The goal of this study was to use 4 prognostic indices to compare survival times of patients who underwent Gamma Knife stereotactic radiosurgery (SRS) to treat melanoma brain metastases. METHODS The authors analyzed 422 consecutive patients (1440 brain metastases) who underwent Gamma Knife SRS. The median total brain tumor volume was 4.7 cm3 (range 0.3–69.3 cm3), and the median number of metastases was 2 (range 1–32). One hundred thirty-two patients underwent whole-brain radiation therapy. Survival times were compared using recursive partitioning analysis (RPA), the Score Index for Radiosurgery (SIR), the Basic Score for Brain Metastases (BSBM), and the Diagnosis-Specific Graded Prognostic Assessment (DS-GPA). RESULTS The overall survival times after SRS were compared. With the RPA index, survival times were 2.6 months (Class III, n = 27), 5.5 months (Class II, n = 348), and 13.0 months (Class I, n = 47). With the DS-GPA index, survival times were 2.8 months (Scores 0–1, n = 67), 4.2 months (Scores 1.5–2.0, n = 143), 6.6 months (Scores 2.5–3.0, n = 111), and 9.4 months (Scores 3.5–4.0, n = 101). With the SIR, survival times were 3.2 months (Scores 0–3, n = 56), 5.8 months (Scores 4–7, n = 319), and 12.7 months (Scores 8–10, n = 47). With the BSBM index, survival times were 2.6 months (BSBM0, n = 47), 5.4 months (BSBM1, n = 282), 11.0 months (BSBM2, n = 86), and 8.8 months (BSBM3, n = 7). The DS-GPA index was the most

http://thejns.org/doi/abs/10.3171/2016.9.JNS161011?mi=67t04w&af=R

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