Tartaglione Tommaso, Brogna Claudia, Cristiano Lara, Verdolotti Tommaso, Pane Marika, Ficociello Luana, Fanelli Lavinia, Colosimo Cesare, Mercuri Eugenio October 5, 2017

In the last few years there has been increasing attention to the involvement of the upper limbs in Duchenne muscular dystrophy (DMD). Both clinical and MRI studies have shown that the first signs of upper limb weakness are related to shoulder muscles(1-3).… Read More...

Sophie Fengler, Inga Liepelt-Scarfone, Kathrin Brockmann, Eva Schäffer, Daniela Berg, Elke Kalbe October 5, 2017

Abstract

Although other nonmotor phenomena representing possible prodromal symptoms of Parkinson’s disease have been described in some detail, the occurrence and characteristics of cognitive decline in this early phase of the disease are less well understood. The aim of this review is to summarize the current state of research on cognitive changes in prodromal PD.

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Daniel R. Schonhaut, Corey T. McMillan, Salvatore Spina, Bradford C. Dickerson, Andrew Siderowf, Michael D. Devous, Richard Tsai, Joseph Winer, David S. Russell, Irene Litvan, Erik D. Roberson, William W. Seeley, Lea T. Grinberg, Joel H. Kramer, Bruce L. Miller, Peter Pressman, Ilya Nasrallah, Suzanne L. Baker, Stephen N. Gomperts, Keith A. Johnson, Murray Grossman, William J. Jagust, Adam L. Boxer, Gil D. Rabinovici October 5, 2017

ABSTRACT

Objective: 18F-flortaucipir (formerly 18F-AV1451 or 18F-T807) binds to neurofibrillary tangles in Alzheimer’s disease (AD), but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have yielded mixed results. We compared in vivo 18F-flortaucipir uptake in patients meeting clinical research criteria for PSP (N=33) to normal controls (N=46) and patients meeting criteria for Parkinson’s disease (PD, N=26).

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Torner, J. C., Brown, R. D. October 5, 2017

Unruptured intracranial aneurysms (UIA) occur in about 2%–3% of the population. Several medical conditions are associated with a UIA presence, including autosomal dominant polycystic kidney disease (ADPKD). Clinicians and patients want to know the risk of aneurysm growth, rupture, or de novo development, predictors of clinical outcomes, and the optimal initial and follow-up screening for individuals with UIA and ADPKD.… Read More...

Gilsanz, P., Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., Mungas, D. M., DeCarli, C., Dean, A., Whitmer, R. A. October 5, 2017

Objective:

To evaluate the association of early-adulthood and mid-adulthood hypertension with dementia in men and women.

Methods:

We evaluated 5,646 members of a diverse integrated health care delivery system who had clinical examinations and health survey data from 1964 to 1973 (mean age 32.7 years; early adulthood) and 1978–1985 (mean age 44.3 years; mid-adulthood) and were members as of January 1, 1996 (mean age 59.8 years).… Read More...

Zeestraten, E. A., Lawrence, A. J., Lambert, C., Benjamin, P., Brookes, R. L., Mackinnon, A. D., Morris, R. G., Barrick, T. R., Markus, H. S. October 5, 2017

Objective:

To determine whether MRI markers, including diffusion tensor imaging (DTI), can predict cognitive decline and dementia in patients with cerebral small vessel disease (SVD).

Methods:

In the prospective St George’s Cognition and Neuroimaging in Stroke study, multimodal MRI was performed annually for 3 years and cognitive assessments annually for 5 years in a cohort of 99 patients with SVD, defined as symptomatic lacunar stroke and confluent white matter hyperintensities (WMH).… Read More...

Weiner, M. W., Crane, P. K., Montine, T. J., Bennett, D. A., Veitch, D. P. October 5, 2017

Traumatic brain injury (TBI) commonly occurs in civilian and military populations. Some epidemiologic studies previously have associated TBI with an increased risk of Alzheimer disease (AD). Recent clinicopathologic and biomarker studies have failed to confirm the relationship of TBI to the development of AD dementia or pathologic changes, and suggest that other neurodegenerative processes might be linked to TBI.… Read More...

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