Norton, D. J., Amariglio, R., Protas, H., Chen, K., Aguirre-Acevedo, D. C., Pulsifer, B., Castrillon, G., Tirado, V., Munoz, C., Tariot, P., Langbaum, J. B., Reiman, E. M., Lopera, F., Sperling, R. A., Quiroz, Y. T. September 7, 2017

Objective:

To cross-sectionally study subjective memory complaints (SMC) in autosomal dominant Alzheimer disease (ADAD).

Methods:

We examined self-reported and study partner–based SMC in 52 young, cognitively unimpaired individuals from a Colombian kindred with early-onset ADAD. Twenty-six carried the PSEN-1 E280A mutation, averaging 7 years of age younger than the kindred’s expected clinical onset.… Read More...

Escudero, D., Guasp, M., Arino, H., Gaig, C., Martinez-Hernandez, E., Dalmau, J., Graus, F. September 7, 2017

Objective:

To report the CNS syndromes of patients ≥60 years of age with antibodies against neuronal surface antigens but no evidence of brain MRI and CSF inflammatory changes.

Methods:

This was a retrospective clinical analysis of patients with antibodies against neuronal surface antigens who fulfilled 3 criteria: age ≥60 years, no inflammatory abnormalities in brain MRI, and no CSF pleocytosis.… Read More...

Bowman, G. L. September 7, 2017

There are approximately 1,000 genes involved in odor recognition and 347 that code for functional receptors. This enables our distinguishing of approximately 4,000–10,000 distinct odorous ligands, a scientific discovery that earned a Nobel Prize in 2004.1 The olfactory nerve (CN1) contains 6–10 million receptor cells whose ciliated dendrites and cell bodies are contained within a specialized (neuro)epithelium located within the posterior nasal cavity (figure).… Read More...

Ahmed Yousef, John L. Robinson, David J. Irwin, Matthew D. Byrne, Linda K. Kwong, Edward B. Lee, Yan Xu, Sharon X. Xie, Lior Rennert, EunRan Suh, Vivianna M. Van Deerlin, Murray Grossman, Virginia M.-Y. Lee and John Q. Trojanowski September 7, 2017

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We ex…

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Masaru Seguchi, Masunari Shibata, Yu Sato, Kota Maekawa, Yotaro Kitano, Takanori Sano, Kazuto Kobayashi, Shigetoshi Shimizu, Fumitaka Miya September 7, 2017

The efficacy of carotid artery stenting (CAS) for patients in the acute poststroke phase has not been established. We investigated the outcome of CAS for patients with symptomatic internal carotid artery (ICA) stenosis in the acute poststroke phase.

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Pamela M. Rist, Monik C. Jiménez, Shelley S. Tworoger, Frank B. Hu, JoAnn E. Manson, Qi Sun, Kathryn M. Rexrode September 7, 2017

Plasma retinol-binding protein 4 (RBP4) levels have been associated with cardiovascular risk factors and risk of coronary heart disease, but little is known about the association between RBP4 and the risk of ischemic stroke. We hypothesized that elevated RBP4 levels would be associated with an increased risk of ischemic stroke among women.… Read More...

Kathrin Doppler, Franziska Frank, Ann-Cathrin Koschker, Karlheinz Reiners, Claudia Sommer September 6, 2017

Abstract

Paranodal demyelination has been discussed as a potential mechanism of nerve fiber damage in diabetic neuropathy (DNP). Studies on human tissue are limited, as nerve biopsies are invasive and only rarely performed in patients with confirmed DNP. Skin biopsy has recently been suggested as a tool to analyze paranodal and nodal changes of myelinated fibers.

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