Galvin, J. E., Howard, D. H., Denny, S. S., Dickinson, S., Tatton, N. October 5, 2017

Objective:

To quantify the socioeconomic burden of frontotemporal degeneration (FTD) compared to previously published data for Alzheimer disease (AD).

Methods:

A 250-item internet survey was administered to primary caregivers of patients with behavioral-variant FTD (bvFTD), primary progressive aphasia, FTD with motor neuron disease, corticobasal syndrome, or progressive supranuclear palsy.… Read More...

Francesco Onorati, Giulia Regalia, Chiara Caborni, Matteo Migliorini, Daniel Bender, Ming-Zher Poh, Cherise Frazier, Eliana Kovitch Thropp, Elizabeth D. Mynatt, Jonathan Bidwell, Roberto Mai, W. Curt LaFrance, Andrew S. Blum, Daniel Friedman, Tobias Loddenkemper, Fatemeh Mohammadpour-Touserkani, Claus Reinsberger, Simone Tognetti, Rosalind W. Picard October 5, 2017

Summary

Objective

New devices are needed for monitoring seizures, especially those associated with sudden unexpected death in epilepsy (SUDEP). They must be unobtrusive and automated, and provide false alarm rates (FARs) bearable in everyday life. This study quantifies the performance of new multimodal wrist-worn convulsive seizure detectors.

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M Manes, A Alberici, E Di Gregorio, L Boccone, E Premi, N Mitro, M.P. Pasolini, C Pani, B Paghera, D Perani, L Orsi, C Costanzi, M Ferrero, A Zoppo, F Tempia, D Caruso, M Grassi, A Padovani, A Brusco, B Borroni October 4, 2017

Abstract

Objective: Spinocerebellar Ataxia 38 (SCA38) is caused by mutations in the ELOVL5 gene, which encodes an elongase involved in the synthesis of polyunsatured fatty acids, including docosahexaenoic acid (DHA). As a consequence, DHA is significantly reduced in the serum of SCA38 subjects.

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Kristin J. Ford, Allen Joop, Raima A. Memon, Kimberly H. Wood, Karlene Ball, Gary R. Cutter, David C. Schwebel, Amy W. Amara October 4, 2017

ABSTRACT

Background

Patients with Parkinson’s disease experience debilitating motor symptoms as well as nonmotor symptoms, such as cognitive dysfunction and sleep disorders. This constellation of symptoms has the potential to negatively influence pedestrian safety. The objective of this study was to investigate the association of motor symptoms, daytime sleepiness, impaired vigilance, and cognitive dysfunction with pedestrian behavior in patients with Parkinson’s disease and healthy older adults.

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Angus D. Macleod, Ingvild Dalen, Ole-Bjørn Tysnes, Jan Petter Larsen, Carl E. Counsell October 4, 2017

ABSTRACT

Objective

The objective of this study was to develop valid prognostic models to predict mortality, dependency, and “death or dependency” for use in newly diagnosed Parkinson’s disease (PD).

Methods

The models were developed in the Parkinsonism Incidence in North-East Scotland study (UK, 198 patients) and validated in the ParkWest study (Norway, 192 patients), cohorts that attempted to identify and follow-up all new PD cases in the study area.

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