Koji Kasanuki, Michael G. Heckman, Nancy N. Diehl, Melissa E. Murray, Shunsuke Koga, Alexandra Soto, Owen A. Ross, Dennis W. Dickson September 26, 2017

ABSTRACT

Background

A number of genetic loci are associated with risk for Parkinson’s disease (PD) based on genome-wide association studies; however, the relationship between genetic variants and nigrostriatal degeneration, which is the structural correlate of parkinsonism, has not been reported.

Objectives

We quantified nigrostriatal dopaminergic integrity with image analysis of putaminal tyrosine hydroxylase immunoreactivity in 492 brains with Lewy body disease and used this pathologic endophenotype to explore possible association with PD genetic variants.

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Alessandro Tessitore, Rosa De Micco, Alfonso Giordano, Federica di Nardo, Giuseppina Caiazzo, Mattia Siciliano, Manuela De Stefano, Antonio Russo, Fabrizio Esposito, Gioacchino Tedeschi September 26, 2017

Abstract

Background: Impulse control disorders can be triggered by dopamine replacement therapies in patients with PD. Using resting-state functional MRI, we investigated the intrinsic brain network connectivity at baseline in a cohort of drug-naive PD patients who successively developed impulse control disorders over a 36-month follow-up period compared with patients who did not.

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Samuel J. Rose, Porter Harrast, Christine Donsante, Xueliang Fan, Valerie Joers, Malú G. Tansey, H.A. Jinnah, Ellen J. Hess September 26, 2017

Abstract

Background: Recent neuroimaging studies implicate nigrostriatal degeneration as a critical factor in producing late-onset parkinsonism in patients with l-dopa-responsive dystonia-causing mutations. However, postmortem anatomical studies do not reveal neurodegeneration in l-dopa-responsive dystonia patients. These contrasting findings make it unclear how parkinsonism develops in l-dopa-responsive dystonia mutation carriers.

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Kari Modalsli Aaberg, Pål Surén, Camilla Lund Søraas, Inger Johanne Bakken, Morten I. Lossius, Camilla Stoltenberg, Richard Chin September 26, 2017

Summary

Objective

The study provides updated information about the distribution of seizures, epilepsies, and etiologies of epilepsy in the general child population, and compares the old and new classification systems from the International League Against Epilepsy (ILAE).

Methods

The study platform was the Norwegian Mother and Child Cohort Study.

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Shane W. Goodwin, Piotr Wilk, M. Karen Campbell, Kathy N. Speechley September 26, 2017

Summary

Objective

Our objective was to examine the relationships of factors associated with children’s emotional well-being 2 years after diagnosis, and to examine if these relationships are mediated or moderated by family factors.

Methods

Data came from a multicenter prospective cohort study of children with newly diagnosed epilepsy from across Canada (Health-Related Quality of Life in Children with Epilepsy Study; HERQULES, n = 373).

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Inkyung Song, Iren Orosz, Inna Chervoneva, Zachary J. Waldman, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Noriko Salamon, Richard Gorniak, Sandra Dewar, Anatol Bragin, Jerome Engel, Michael R. Sperling, Richard Staba, Shennan A. Weiss September 26, 2017

Summary

Objective

Differentiating pathologic and physiologic high-frequency oscillations (HFOs) is challenging. In patients with focal epilepsy, HFOs occur during the transitional periods between the up and down state of slow waves. The preferred phase angles of this form of phase-event amplitude coupling are bimodally distributed, and the ripples (80–150 Hz) that occur during the up-down transition more often occur in the seizure-onset zone (SOZ).

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