Jordan S. Farrell, Roberto Colangeli, Marshal D. Wolff, Alexandra K. Wall, Thomas J. Phillips, Antis George, Paolo Federico, G. Campbell Teskey September 3, 2017

Summary

A recent article by Farrell et al. characterizes the phenomenon, mechanisms, and treatment of a local and severe hypoperfusion/hypoxia event that occurs in brain regions following a focal seizure. Given the well-established role of cerebral ischemia/hypoxia in brain damage and behavioral dysfunction in other clinical settings (e.g., stroke, cerebral vasospasm), we put forward a new theory: postictal hypoperfusion/hypoxia is responsible for the negative consequences associated with seizures.

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Nicola Specchio, Marcello Bellusci, Nicola Pietrafusa, Marina Trivisano, Luca Palma, Federico Vigevano September 3, 2017

Summary

Objective

This study aimed to identify early clinical, magnetic resonance imaging (MRI), and electroencephalographic (EEG) characteristics of neuronal ceroid lipofuscinosis type 2 (CLN2) disease to enable early diagnosis, thus providing the key to early treatment, and optimized care and outcomes.

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Jesús-Servando Medel-Matus, Ashley Reynolds, Don Shin, Raman Sankar, Andrey Mazarati September 3, 2017

Summary

This study examined whether Toll-like receptors 2 (TLR2) contribute to rapid kindling epileptogenesis. A TLR2 agonist, lipoteichoic acid (LTA), LTA antibody (LTA-A), or normal saline (control) was administered daily over 3 consecutive days, unilaterally into ventral hippocampus of adult male Wistar rats.

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Elena Freri, Sara Matricardi, Francesca Gozzo, Massimo Cossu, Tiziana Granata, Laura Tassi September 3, 2017

Summary

Objective

To report the presurgical workup, surgical procedures, and outcomes in a series of pediatric patients with drug-resistant epilepsy involving the perisylvian/insular regions.

Methods

We retrospectively assessed 16 pediatric patients affected by drug-resistant focal epilepsy involving perisylvian/insular regions, who consecutively underwent tailored resective surgery.

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Diede W. M. Broekaart, Jackelien Scheppingen, Karlijne W. Geijtenbeek, Mark R. J. Zuidberg, Jasper J. Anink, Johannes C. Baayen, Angelika Mühlebner, Eleonora Aronica, Jan A. Gorter, Erwin A. Vliet September 3, 2017

Summary

Objective

Inhibition of the mammalian target of rapamycin (mTOR) pathway reduces epileptogenesis in various epilepsy models, possibly by inhibition of inflammatory processes, which may include the proteasome system. To study the role of mTOR inhibition in the regulation of the proteasome system, we investigated (immuno)proteasome expression during epileptogenesis, as well as the effects of the mTOR inhibitor rapamycin.

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Bertrand Mathon, Franck Bielle, Séverine Samson, Odile Plaisant, Sophie Dupont, Anne Bertrand, Richard Miles, Vi-Huong Nguyen-Michel, Virginie Lambrecq, Ana Laura Calderon-Garcidueñas, Charles Duyckaerts, Alexandre Carpentier, Michel Baulac, Philippe Cornu, Claude Adam, Stéphane Clemenceau, Vincent Navarro September 3, 2017

Summary

Objective

The reasons for failure of surgical treatment for mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) remain unclear. This retrospective study analyzed seizure, cognitive, and psychiatric outcomes, searching for factors associated with seizure relapse or cognitive and psychiatric deterioration after MTLE-HS surgery.

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Birgit Frauscher, Fabrice Bartolomei, Katsuhiro Kobayashi, Jan Cimbalnik, Maryse A. Klooster, Stefan Rampp, Hiroshi Otsubo, Yvonne Höller, Joyce Y. Wu, Eishi Asano, Jerome Engel, Philippe Kahane, Julia Jacobs, Jean Gotman September 3, 2017

Summary

Modern electroencephalographic (EEG) technology contributed to the appreciation that the EEG signal outside the classical Berger frequency band contains important information. In epilepsy, research of the past decade focused particularly on interictal high-frequency oscillations (HFOs) 80 Hz. The first large application of HFOs was in the context of epilepsy surgery.

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Anna Mira Loesch, Hannah Steger, Claudia Losher, Elisabeth Hartl, Jan Rémi, Christian Vollmar, Soheyl Noachtar September 3, 2017

Summary

Objective

To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes.

Methods

We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analysis and Fisher’s exact test.

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Jon D. Duke, Patrick B. Ryan, Marc A. Suchard, George Hripcsak, Peng Jin, Christian Reich, Marie-Sophie Schwalm, Yuriy Khoma, Yonghui Wu, Hua Xu, Nigam H. Shah, Juan M. Banda, Martijn J. Schuemie September 3, 2017

Summary

Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam. To help address this question, the Observational Health Data Sciences and Informatics research network conducted a retrospective observational new-user cohort study of seizure patients exposed to levetiracetam (n = 276,665) across 10 databases.

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Felix Podewils, Marie Suesse, Julia Geithner, Bernadette Gaida, Zhong I. Wang, Julia Lange, Alexander Dressel, Matthias Grothe, Christof Kessler, Soenke Langner, Uwe Runge, Christian G. Bien September 3, 2017

Summary

Objective

The increasing incidence of new-onset seizures with age is well known. Often, the etiology cannot be clarified. In the present study, patients with unprovoked late-onset seizures and without known neoplasm, who might have had paraneoplastic encephalitis, were investigated for a potentially underlying autoimmunity.

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