Su Jin Chung, Jeong-Hyeon Shin, Kyoo Ho Cho, Yoonju Lee, Young H. Sohn, Joon-Kyung Seong, Phil Hyu Lee September 10, 2017

ABSTRACT

Background

Cortical neural correlates of ongoing cognitive decline in Parkinson’s disease (PD) have been suggested; however, the role of subcortical structures in longitudinal change of cognitive dysfunction in PD has not been fully investigated. Here, we used automatic analysis to explore subcortical brain structures in patients with PD with mild cognitive impairment that converts into PD with dementia.

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Patricia García-Sanz, Lorena Orgaz, Guillermo Bueno-Gil, Isabel Espadas, Eva Rodríguez-Traver, Jaime Kulisevsky, Antonia Gutierrez, José C. Dávila, Rosa A. González-Polo, José M. Fuentes, Pablo Mir, Carlos Vicario, Rosario Moratalla September 10, 2017

Abstract

Background

Heterozygous mutations in the GBA1 gene, which encodes the lysosomal enzyme β-glucocerebrosidase-1, increase the risk of developing Parkinson’s disease, although the underlying mechanisms remain unclear. The aim of this study was to explore the impact of the N370S-GBA1 mutation on cellular homeostasis and vulnerability in a patient-specific cellular model of PD.

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Ana Castro Caldas, Johannes Levin, Ruth Djaldetti, Olivier Rascol, Gregor Wenning, Joaquim J. Ferreira, September 10, 2017

ABSTRACT

Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause. Although many clinical trials have been conducted, there is still no treatment that cures the disease or slows its progression. We sought to assess the clinical trials, methodology, and quality of reporting of clinical trails conducted in MSA patients.

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