Frank Steigerwald, Lars Timmermann, Andrea Kühn, Alfons Schnitzler, Martin M. Reich, Anna Dalal Kirsch, Michael Thomas Barbe, Veerle Visser-Vandewalle, Julius Hübl, Christoph van Riesen, Stefan Jun Groiss, Alexia-Sabine Moldovan, Sherry Lin, Stephen Carcieri, Ljubomir Manola, Jens Volkmann November 22, 2017

ABSTRACT

Background

Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson’s disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations.

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Valtteri Kaasinen, Tero Vahlberg November 22, 2017

Abstract

A meta-analysis of 141 PET and SPECT studies that have investigated striatal presynaptic dopamine function in Parkinson’s disease (PD) was performed. Subregional estimates of striatal dopamine metabolism are presented. The aromatic L-amino-acid decarboxylase (AADC) defect appears to be consistently smaller than the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) defects, suggesting up-regulation of AADC function in PD.

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