Dan-Dan Wang, Yue-Shan Piao, Ingmar Blumcke, Roland Coras, Wen-Jing Zhou, Qiu-Ping Gui, Cui-Cui Liu, Jing-Xia Hu, Li-Zhen Cao, Guo-Jun Zhang, De-Hong Lu September 3, 2017

Summary

Objective

In 2011, the International League Against Epilepsy (ILAE) proposed a consensus classification system of focal cortical dysplasia (FCD) to distinguish clinicopathological subtypes, for example, “isolated” FCD type Ia–c and IIa–b, versus “associated” FCD type IIIa–d. The histopathological differentiation of FCD type I and III variants remains, however, a challenging issue in everyday practice.

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Anna Edelvik, Charles Taft, Gerd Ekstedt, Kristina Malmgren September 3, 2017

Summary

Objective

To evaluate health-related quality of life (HRQOL) and emotional well-being in resective epilepsy surgery and nonoperated patients at long-term follow-up.

Methods

This is a prospective cohort study where patients undergoing presurgical work-up during 1995–1998 completed the Short-Form Health Survey (SF-36) and the Hospital Anxiety and Depression scale (HAD) at baseline, and 2 and 14 years after resective surgery or presurgical evaluation (nonoperated patients).

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Isabelle Niespodziany, Jean-Michel Rigo, Gustave Moonen, Alain Matagne, Henrik Klitgaard, Christian Wolff September 3, 2017

Summary

Brivaracetam (BRV) is a selective, high-affinity ligand for synaptic vesicle protein 2A (SV2A), recently approved as adjunctive treatment for drug-refractory partial-onset seizures in adults. BRV binds SV2A with higher affinity than levetiracetam (LEV), and was shown to have a differential interaction with SV2A.

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Oscar H. Del Brutto, Gianfranco Arroyo, Victor J. Del Brutto, Mauricio Zambrano, Héctor H. García September 3, 2017

Summary

Objective

Using a large-scale population-based study, we aimed to assess prevalence and patterns of presentation of neurocysticercosis (NCC) and its relationship with epilepsy in community-dwellers aged ≥20 years living in Atahualpa (rural Ecuador).

Methods

In a three-phase epidemiological study, individuals with suspected seizures were identified during a door-to-door survey and an interview (phase I).

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Nina Dupuis, Julie Enderlin, Jeremy Thomas, Béatrice Desnous, Pascal Dournaud, Delphine Allorge, Stéphane Auvin September 3, 2017

Summary

Objective

Perampanel (PER) is a selective noncompetitive antagonist at α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, the first of its class approved for the adjunctive treatment of partial onset seizures and generalized seizures. This study explored anti-ictogenic and antiepileptogenic effects of PER in rats at different stages of development.

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Michael H. K. Bendels, Eileen Wanke, Norman Schöffel, Jan Bauer, David Quarcoo, David A. Groneberg September 3, 2017

Summary

Objective

The study aims to elucidate the state of gender equality in epilepsy research, analyzing the representation of female authorships from 2008 to 2016.

Methods

Gendermetrics aided in analyzing 106,282 authorships from 22,180 epilepsy-related original research articles. The key methodology was the combined analysis of the relative frequency and the odds ratio of female authorships.

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