IqYmune® is an effective maintenance treatment for multifocal motor neuropathy: a randomised,…

Intravenous immunoglobulin (IVIg) is the gold‐standard for maintenance treatment of multifocal motor neuropathy (MMN). This phase III, randomised, double‐blind, multicentre, active‐control, crossover study, aimed to evaluate the…

Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a…

ABSTRACT Background: MSA is a fatal neurodegenerative disease characterized by autonomic failure and severe motor impairment. Its main pathological hallmark is the accumulation of α‐synuclein in oligodendrocytes, leading to glial and…

Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr…

DIP/Dpr interactions help to pattern the Drosophila nervous system. Cosmanescu et al. quantify their interactions and map DIP expression in medulla neurons. Structural studies identify specificity determinants of DIP/Dpr interactions and…

Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural…

Xu et al. demonstrate that DIP-α and Dpr6/10 heterophilic and DIP-α homophilic interactions regulate multiple aspects of circuit assembly including layer-specific targeting, cell survival, and synapse number and distribution in the…