Vimlesh Soni, Pratibha Singhi, Arushi Gahlot Saini, Prabhjot Malhi, Radha K. Ratho, Baijayantimala Mishra, Sunit C. Singhi September 3, 2017

An acute symptomatic seizure is defined as a clinical seizure occurring in close temporal relationship with an acute central nervous system (CNS) insult, which may be metabolic, toxic, structural, infectious, or inflammatory [1]. Overall acute symptomatic seizures represent nearly 40% of total seizures [2], 40% of all cases of afebrile seizures [3] and 50–70% of status epilepticus episodes [4].… Read More...

Maxine Dibué-Adjei, Igor Fischer, Hans-Jakob Steiger, Marcel Alexander Kamp September 3, 2017

Severe myoclonic epilepsy of infancy (SMEI) was first decribed by Charlotte Dravet in 1978 and later renamed to “Dravet Syndrome” to include atypical and borderline forms as well as to describe the syndrome that persists beyond infancy [11,12]. Dravet syndrome (DS) is an infantile-onset epileptic encephalopathy of childhood involving intractable seizures, recurrent status epilepticus and cognitive decline [13,14].… Read More...

Peter L. Fisher, Adam J. Noble September 3, 2017

Anxiety and depression are highly prevalent in people with epilepsy (PWE); approximately one third of PWE meet diagnostic criteria for an anxiety and/or a depressive disorder during their lifetime [1]. Anxiety disorders are at least as prevalent as depressive disorders, and frequently co-occur with substantial adverse economic, societal and personal consequences [2–4].… Read More...

Ioanna Rizou, Veronique De Gucht, Antigone Papavasiliou, Stan Maes September 3, 2017

The literature suggests that interventions focusing on changing illness appraisals of young individuals as well as enhancing coping skills may be an effective treatment for pediatric psychosocial maladjustment [1–4]. This is especially true for children and adolescents with epilepsy. Epilepsy is amongst the most prevalent neurological diseases, with a substantial negative impact not only on the physical, but also on the cognitive, social, emotional, and behavioural functioning of the patient.… Read More...

Josef Finsterer, Sinda Zarrouk-Mahjoub September 3, 2017

Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare syndromic mitochondrial disorder (MID) with a broad phenotypic but narrow genotypic heterogeneity. One of the predominant phenotypic features in addition to myopathy is epilepsy. The most frequent seizure type in MERRF is generalised myoclonic seizure but also focal myoclonic, focal atonic, generalised tonic-clonic, generalised atonic, generalised myoclonic-atonic, typical absences, or tonic-clonic seizures of unknown onset have been reported.… Read More...

Sujata Roshan, Vinod Puri, Neera Chaudhry, Anu Gupta, Sumit Kumar Rabi September 3, 2017

Sleep disorders are common in patients with epilepsy. In addition to excessive daytime sleepiness (EDS), many primary sleep disorders such as obstructive sleep apnea (OSA), and sleep-maintenance insomnia are 2 to 3 times more prevalent in people with epilepsy than the general populations [1].… Read More...

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