Zhidong Cen, Yuting Lou, Yufan Guo, Jianda Wang, Jianhua Feng September 3, 2017

SCN9A gene encodes voltage-gated sodium channel NaV1.7 and is associated with a group of heterogeneous phenotypes. Heterozygous gain-of-function SCN9A mutations have been linked to inherited erythromelalgia (IEM), paroxysmal extreme pain disorder (PEPD), and small-fiber neuropathy (SFN), while recessive loss-of-function SCN9A mutations have been linked to congenital insensitivity to pain (CIP).… Read More...

Jennifer Williams, Gerard Mullins, Norman Delanty, Bede Peter, Colin P. Doherty September 3, 2017

Kramer et al first described transient MRI abnormalities in a patient with focal status epilepticus in 1987 [1]. Since then, increased use and availability of MRI has revealed a wide spectrum of neuroimaging abnormalities in the acuteictal period. The appearance of these abnormalities can sometimes pose diagnostic dilemmas for clinicians who may encounter them in a variety of clinical scenarios and are unsure about their significance.… Read More...

Zeynab Mohammadpoory, Mahda Nasrolahzadeh, Javad Haddadnia September 3, 2017

Epilepsy is a neurological disorder, characterized by the recurrent sudden abnormal reactions of the brain [1]. Epileptic seizures resulting from excessive neuronal discharge are usually accompanied by a disturbance of movement, sensation, mood, or mental function [2,3]. There are about 37 million patients around the world suffering from this kind of chronic neurological disorder.… Read More...

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