Daniel R. Schonhaut, Corey T. McMillan, Salvatore Spina, Bradford C. Dickerson, Andrew Siderowf, Michael D. Devous, Richard Tsai, Joseph Winer, David S. Russell, Irene Litvan, Erik D. Roberson, William W. Seeley, Lea T. Grinberg, Joel H. Kramer, Bruce L. Miller, Peter Pressman, Ilya Nasrallah, Suzanne L. Baker, Stephen N. Gomperts, Keith A. Johnson, Murray Grossman, William J. Jagust, Adam L. Boxer, Gil D. Rabinovici October 5, 2017

ABSTRACT

Objective: 18F-flortaucipir (formerly 18F-AV1451 or 18F-T807) binds to neurofibrillary tangles in Alzheimer’s disease (AD), but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have yielded mixed results. We compared in vivo 18F-flortaucipir uptake in patients meeting clinical research criteria for PSP (N=33) to normal controls (N=46) and patients meeting criteria for Parkinson’s disease (PD, N=26).

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Torner, J. C., Brown, R. D. October 5, 2017

Unruptured intracranial aneurysms (UIA) occur in about 2%–3% of the population. Several medical conditions are associated with a UIA presence, including autosomal dominant polycystic kidney disease (ADPKD). Clinicians and patients want to know the risk of aneurysm growth, rupture, or de novo development, predictors of clinical outcomes, and the optimal initial and follow-up screening for individuals with UIA and ADPKD.… Read More...

Gilsanz, P., Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., Mungas, D. M., DeCarli, C., Dean, A., Whitmer, R. A. October 5, 2017

Objective:

To evaluate the association of early-adulthood and mid-adulthood hypertension with dementia in men and women.

Methods:

We evaluated 5,646 members of a diverse integrated health care delivery system who had clinical examinations and health survey data from 1964 to 1973 (mean age 32.7 years; early adulthood) and 1978–1985 (mean age 44.3 years; mid-adulthood) and were members as of January 1, 1996 (mean age 59.8 years).… Read More...

Zeestraten, E. A., Lawrence, A. J., Lambert, C., Benjamin, P., Brookes, R. L., Mackinnon, A. D., Morris, R. G., Barrick, T. R., Markus, H. S. October 5, 2017

Objective:

To determine whether MRI markers, including diffusion tensor imaging (DTI), can predict cognitive decline and dementia in patients with cerebral small vessel disease (SVD).

Methods:

In the prospective St George’s Cognition and Neuroimaging in Stroke study, multimodal MRI was performed annually for 3 years and cognitive assessments annually for 5 years in a cohort of 99 patients with SVD, defined as symptomatic lacunar stroke and confluent white matter hyperintensities (WMH).… Read More...

Weiner, M. W., Crane, P. K., Montine, T. J., Bennett, D. A., Veitch, D. P. October 5, 2017

Traumatic brain injury (TBI) commonly occurs in civilian and military populations. Some epidemiologic studies previously have associated TBI with an increased risk of Alzheimer disease (AD). Recent clinicopathologic and biomarker studies have failed to confirm the relationship of TBI to the development of AD dementia or pathologic changes, and suggest that other neurodegenerative processes might be linked to TBI.… Read More...

van Eijk, R. P. A., Jones, A. R., Sproviero, W., Shatunov, A., Shaw, P. J., Leigh, P. N., Young, C. A., Shaw, C. E., Mora, G., Mandrioli, J., Borghero, G., Volanti, P., Diekstra, F. P., van Rheenen, W., Verstraete, E., Eijkemans, M. J. C., Veldink, J. H., Chio, A., Al-Chalabi, A., van den Berg, L. H., van Es, M. A., For UKMND-LiCALS and LITALS Study Group October 5, 2017

Objective:

To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders.

Methods:

Individual participant data were obtained from 3 randomized trials investigating the efficacy of lithium carbonate.… Read More...

Nurmonen, H. J., Huttunen, T., Huttunen, J., Kurki, M. I., Helin, K., Koivisto, T., von und zu Fraunberg, M., Jääskeläinen, J. E., Lindgren, A. E. October 5, 2017

Objective:

To define the association of autosomal dominant polycystic kidney disease (ADPKD) with the characteristics of aneurysmal subarachnoid hemorrhage (aSAH) and unruptured intracranial aneurysm (IA) disease.

Methods:

We fused data from the Kuopio Intracranial Aneurysm database (n = 4,436 IA patients) and Finnish nationwide registries into a population-based series of 53 IA patients with ADPKD to compare the aneurysm- and patient-specific characteristics of IA disease in ADPKD and in the general IA population, and to identify risks for de novo IA formation.… Read More...

Galvin, J. E., Howard, D. H., Denny, S. S., Dickinson, S., Tatton, N. October 5, 2017

Objective:

To quantify the socioeconomic burden of frontotemporal degeneration (FTD) compared to previously published data for Alzheimer disease (AD).

Methods:

A 250-item internet survey was administered to primary caregivers of patients with behavioral-variant FTD (bvFTD), primary progressive aphasia, FTD with motor neuron disease, corticobasal syndrome, or progressive supranuclear palsy.… Read More...

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