The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and…

The BDNF Val66Met prodomain is associated with reduced ability to extinguish fear memories. Giza et al. show that the BDNF Met prodomain eliminates spines in vCA1 neurons projecting to the PL, diminishing their capacity to adapt during…

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical…

Park et al. demonstrate that brain somatic mutations in MTOR result in defective neuronal ciliogenesis in FMCDs. The aberrant accumulation of OFD1 by impaired autophagy is responsible for defective ciliogenesis. Moreover, defective…

How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse

Interneurons are key actors in the input-output transformations of many brain regions. Combining experiment and theory, Drinnenberg and Franke et al. show how a single interneuron type in the retina shapes the functional diversity of the…