John M. Pellock, Alexis Arzimanoglou, O'Neill D'Cruz, Gregory L. Holmes, Douglas Nordli, Shlomo Shinnar, September 3, 2017

Summary

Expediting pediatric access to new antiseizure drugs is particularly compelling, because epileptic seizures are the most common serious neurological symptom in children. Analysis of antiepileptic drug (AED) efficacy outcomes of randomized controlled trials, conducted during the past 20 years in different populations and a broad range of study sites and countries, has shown considerable consistency for each drug between adult and pediatric populations.

Read More...
Carolina Ciumas, Agathe Laurent, Mani Saignavongs, Faustine Ilski, Julitta Bellescize, Eleni Panagiotakaki, Karine Ostrowsky-Coste, Alexis Arzimanoglou, Vania Herbillon, Danielle Ibarrola, Philippe Ryvlin September 3, 2017

Summary

Objective

We hypothesized that children with benign childhood epilepsy with centrotemporal spikes (BCECTS) might have altered social cognitive skills and underlying neural networks.

Methods

We studied 13 patients with BCECTS and 11 age-matched controls using event-related functional magnetic resonance imaging (fMRI) with an emotional discrimination task consisting of viewing happy, fearful, scrambled, and neutral faces.

Read More...
Mayara Vendramin Pasquetti, Letícia Meier, Samanta Loureiro, Marcelo Ganzella, Bernardo Junges, Letícia Barbieri Caus, Alexandre Umpierrez Amaral, David M. Koeller, Stephen Goodman, Michael Woontner, Diogo Onofre Gomes de Souza, Moacir Wajner, Maria Elisa Calcagnotto September 3, 2017

Summary

Objectives

Glutaric acidemia type I (GA-I) is an inherited neurometabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase (GCDH) and characterized by increased levels of glutaric, 3-OH-glutaric, and glutaconic acids in the brain parenchyma. The increment of these organic acids inhibits glutamate decarboxylase (GAD) and consequently lowers the γ-aminobutyric acid (GABA) synthesis.

Read More...
Monica Puligheddu, Miriam Melis, Giuliano Pillolla, Giulia Milioli, Liborio Parrino, Giovanni Mario Terzano, Sonia Aroni, Claudia Sagheddu, Francesco Marrosu, Marco Pistis, Anna Lisa Muntoni September 3, 2017

Summary

Objective

Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE]). Traditional antiepileptic drugs are effective in about 55% of patients, whereas the rest remains refractory.

Read More...
Emily L. Johnson, Peter W. Kaplan September 3, 2017

Summary

Objective

Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3–0.9% of the world’s population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy.

Methods

We performed literature searches on the following terms: transgender AND epilepsy, transgender AND neurology, gender dysphoria AND epilepsy, gender dysphoria AND neurology.

Read More...
Luigi Maccotta, Mayra A. Lopez, Babatunde Adeyemo, Beau M. Ances, Brian K. Day, Lawrence N. Eisenman, Joshua L. Dowling, Eric C. Leuthardt, Bradley L. Schlaggar, Robert Edward Hogan September 3, 2017

Summary

Objectives

Specific changes in the functional connectivity of brain networks occur in patients with epilepsy. Yet whether such changes reflect a stable disease effect or one that is a function of active seizure burden remains unclear. Here, we longitudinally assessed the connectivity of canonical cognitive functional networks in patients with intractable temporal lobe epilepsy (TLE), both before and after patients underwent epilepsy surgery and achieved seizure freedom.

Read More...
Tyler E. Gaston, E. Martina Bebin, Gary R. Cutter, Yuliang Liu, Jerzy P. Szaflarski, September 3, 2017

Summary

Objective

To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were monitored to identify interactions between CBD and AEDs.

Methods

In 39 adults and 42 children, CBD dose was started at 5 mg/kg/day and increased every 2 weeks by 5 mg/kg/day up to a maximum of 50 mg/kg/day.

Read More...
Simone Beretta, Davide Carone, Clara Zanchi, Elisa Bianchi, Marta Pirovano, Claudia Trentini, Giada Padovano, Matteo Colombo, Diletta Cereda, Sofia Scanziani, Giorgia Giussani, Sara Gasparini, Graziella Bogliun, Carlo Ferrarese, Ettore Beghi, September 3, 2017

Summary

Objective

The new epilepsy definition adopted by the International League Against Epilepsy (ILAE) includes patients with one unprovoked seizure with a probability of further seizures, similar to the general recurrence risk after two unprovoked seizures, occurring in a 10-year period.

Read More...

Andoird App
Loading...