High-frequency oscillations: The state of clinical research

Summary Modern electroencephalographic (EEG) technology contributed to the appreciation that the EEG signal outside the classical Berger frequency band contains important information. In epilepsy, research of the past decade focused…

Increased expression of (immuno)proteasome subunits during epileptogenesis is attenuated by…

Summary ObjectiveInhibition of the mammalian target of rapamycin (mTOR) pathway reduces epileptogenesis in various epilepsy models, possibly by inhibition of inflammatory processes, which may include the proteasome system. To study the role…

Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal…

Summary Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined…

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Summary The biologic processes underlying epileptogenesis following a brain insult are not fully understood, but several lines of evidence suggest that hyperphosphorylation of tau may be an important factor in these processes. To provide…