Brexanolone as Adjunctive Therapy in Super-Refractory Status Epilepticus

ABSTRACT Objective: Super-refractory status epilepticus (SRSE) is a life-threatening form of status epilepticus that continues or recurs despite 24 hours or more of anesthetic treatment. We conducted a multi-center, phase 1/2 study in SRSE…

Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia

ObjectiveThe brain blood vessels of patients with type 2 diabetes and dementia have deposition of amylin, an amyloidogenic hormone cosecreted with insulin. It is not known whether vascular amylin deposition is a consequence or a trigger of…

Very high-frequency oscillations: Novel biomarkers of the epileptogenic zone

ObjectiveIn the present study, we aimed to investigate depth electroencephalographic (EEG) recordings in a large cohort of patients with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) between…