Euloge Ibinga, Michel Druet-Cabanac, Marc Harris Dassi Tchoupa Revegue, Jean Engohang-Ndong, Ulrick Bisvigou, Simon Jonas Ategbo, Pierre-Marie Preux, Edgard Brice Ngoungou July 17, 2019

Epilepsy is a common disorder that occurs worldwide in all age groups and without distinction of gender. There are many superstitious beliefs in African counties about etiology of epilepsy [1–5]. In some of these countries, traditional healers, teachers, and students have linked epilepsy to spiritual attacks and witchcraft.… Read More...

admin July 17, 2019

Abstract

Several morphological changes, centered in/around Purkinje cells (PCs), have been identified in the cerebellum of essential tremor (ET) patients. These changes have not been contextualized within a broader degenerative disease spectrum, limiting their interpretability. To address this, we compared the severity and patterning of degenerative changes within the cerebellar cortex in patients with ET, other neurodegenerative disorders of the cerebellum (spinocerebellar ataxias (SCAs), multiple system atrophy (MSA)], and other disorders that may involve the cerebellum [Parkinson’s disease (PD), dystonia].… Read More...

Scott T. Demarest, Heather E. Olson, Angela Moss, Elia Pestana‐Knight, Xiaoming Zhang, Sumit Parikh, Lindsay C. Swanson, Katherine D. Riley, Grace A. Bazin, Katie Angione, Lisa‐Marie Niestroj, Dennis Lal, Elizabeth Juarez‐Colunga, Tim A. Benke July 17, 2019

Abstract

Objective

The cyclin‐dependent kinase like 5 (CDKL5) gene is a known cause of early onset developmental and epileptic encephalopathy, also known as CDKL5 deficiency disorder (CDD). We sought to (1) provide a description of seizure types in patients with CDD, (2) provide an assessment of the frequency of seizure‐free periods and cortical visual impairment (CVI), (3) correlate these features with genotype and gender, and (4) correlate these features with developmental milestones.… Read More...

Mustafa Gokce July 17, 2019

American Journal of Alzheimer’s Disease &Other Dementias®, Ahead of Print.
Background:The most common type of dementia is an Alzheimer’s disease which is a major concern in growing chronic diseases in the geriatric society, and its connection with biochemistry has not been sufficiently understood.Objective:This study aims to evaluate the effects of blood biochemistry on Alzheimer’s disease.Method:Eight participants aged 55+ with Alzheimer’s disease were analyzed.… Read More...

Randolph W. Evans July 17, 2019

Two cases are reported of migraineurs who reported Raynaud’s phenomenon (RP) exacerbated while taking monoclonal antibodies to the calcitonin gene‐related peptide (CGRP) ligand (fremanezumab and galcanezumab) and 1 case of new onset RP while taking the CGRP receptor antagonist (erenumab). The prevalence of primary and secondary RP, causes of secondary RP, co‐morbidity with migraine, and medications which might induce or exacerbate RP are reviewed.… Read More...

Ioanna Spanou, Anastasia Bougea, George Liakakis, Konstantina Rizonaki, Evangelos Anagnostou, Leonidas Duntas, Evangelia Kararizou July 17, 2019

Background

Migraine, tension‐type headache, and hypothyroidism constitute very common medical conditions. Headache is one of the most common symptoms of hypothyroidism, occurring in approximately one‐third of the patients. To date, data about the relationship between migraine and tension‐type headache and thyroid dysfunction, and in particular hypothyroidism have been contradictory, while the underlying pathophysiological basis explaining this association is still unclear.… Read More...

Caroline M Kopruszinski July 17, 2019

Cephalalgia, Ahead of Print.
AimEvaluation of cannabinoid receptor agonists in a preclinical model of medication overuse headache.MethodsFemale Sprague Dawley rats received graded intraperitoneal doses of WIN55,212-2 or Δ-9-tetrahydrocannabinol (Δ-9-THC). Antinociception (tail-flick test), catalepsy and hypomotility (open field test) and impairment of motor function (rotarod test) were assessed to establish effective dosing.… Read More...

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