Masataka Nanto, Yudai Goto, Hiroyuki Yamamoto, Seisuke Tanigawa, Michiko Takado, Takahiro Ogawa, Yoshikazu Nakahara September 15, 2017

Carotid artery stenting has emerged as an alternative to carotid endarterectomy especially in patients with high risk of carotid endarterectomy. Older age (≥80 years old) was recognized as one of the high risk factors of carotid endarterectomy. However, the association between older age and increased risk of adverse events for carotid artery stenting has been reported.… Read More...

Xianwei Huang, Fazel Naghdy, Golshah Naghdy, Haiping Du, Catherine Todd September 15, 2017

Robot-assisted therapy is regarded as an effective and reliable method for the delivery of highly repetitive training that is needed to trigger neuroplasticity following a stroke. However, the lack of fully adaptive assist-as-needed control of the robotic devices and an inadequate immersive virtual environment that can promote active participation during training are obstacles hindering the achievement of better training results with fewer training sessions required.… Read More...

H. Zhou, E. Marrosu, P. Ala, F. Muntoni September 14, 2017

Collagen VI-related congenital muscular dystrophies (COL6-CMD) are the second most common diagnosis in congenital muscular dystrophies, according to a recent retrospective review performed by our centre on genetic studies in childhood neuromuscular diseases in the UK population. The collagen VI-related myopathies, ranging from severe Ullrich congenital muscular dystrophy (UCMD) to mild Bethlem myopathy (BM) and intermediate clinical phenotypes, are caused by mutations in one of the genes that encode the three major α-chains of collagen type VI, COL6A1, COL6A2 and COL6A3.… Read More...

Michelle E. Fullard, Sharon X. Xie, Ken Marek, Matthew Stern, Danna Jennings, Andrew Siderowf, Allison W. Willis, Alice S. Chen-Plotkin September 14, 2017

ABSTRACT

Background

Lower vitamin D levels have been associated with manifest Parkinson’s disease, prompting the hypothesis that vitamin D insufficiency or deficiency may increase risk for PD.

Objectives

To evaluate vitamin D levels in a population at risk for developing PD.

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Chris Frost, Amy Mulick, Rachael I. Scahill, Gail Owen, Elizabeth Aylward, Blair R. Leavitt, Alexandra Durr, Raymund A. C. Roos, Beth Borowsky, Julie C. Stout, Ralf Reilmann, Douglas R. Langbehn, Sarah J. Tabrizi, Cristina Sampaio, September 14, 2017

ABSTRACT

Objectives

The purpose of this study was to inform the design of randomized clinical trials in early-stage manifest Huntington’s disease through analysis of longitudinal data from TRACK-Huntington’s Disease (TRACK-HD), a multicenter observational study.

Methods

We compute sample sizes required for trials with candidate clinical, functional, and imaging outcomes, whose aims are to reduce rates of change.

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admin September 14, 2017

Collagen VI-related congenital muscular dystrophies (COL6-CMD) are the second most common diagnosis in congenital muscular dystrophies, according to a recent retrospective review performed by our centre on genetic studies in childhood neuromuscular diseases in the UK population. The collagen VI-related myopathies, ranging from severe Ullrich congenital muscular dystrophy (UCMD) to mild Bethlem myopathy (BM) and intermediate clinical phenotypes, are caused by mutations in one of the genes that encode the three major α-chains of collagen type VI, COL6A1, COL6A2 and COL6A3.… Read More...

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