Choi, S.-Y., Kim, H.-J., Kim, J.-S. November 16, 2017

Objective:

To determine the role of the medial longitudinal fasciculus (MLF) in conveying vestibular signals.

Methods:

In 10 patients with isolated acute unilateral internuclear ophthalmoplegia (INO) due to an acute stroke, we performed comprehensive vestibular evaluation using video-oculography, head impulse tests with a magnetic search coil technique, bithermal caloric tests, tests for the ocular tilt reaction, and measurements of subjective visual vertical and cervical and ocular vestibular evoked myogenic potentials (VEMPs).… Read More...

Yoshitaka Yamaguchi, Mikito Hayakawa, Naoto Kinoshita, Chiaki Yokota, Toshiya Ishihara, Kazunori Toyoda November 16, 2017

A 63-year-old woman with end-stage renal disease on maintenance hemodialysis discontinued her medication for rheumatoid arthritis with prednisolone and azathioprine. One month later, she was admitted because of consciousness disturbance and right hemiparesis. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed multiple hyperintensities in her left frontal and parietal lobes.… Read More...

Yanling Liang, Jia Chen, Xuan Zheng, Zhiyi Chen, Yuming Liu, Siying Li, Xiaobo Fang November 16, 2017

The neuroprotective effects of kallidinogenase against acute cerebral infarction have been demonstrated, and the use of microbubbles has been suggested as a therapeutic mechanism for drug delivery. This study was designed to investigate the optimal parameters for preparing kallidinogenase-loaded microbubbles (KLMs) and to evaluate the effects of KLM-targeted therapy on neurogenesis and angiogenesis following experimental acute cerebral infarction in rats.… Read More...

Raffaella Willmann, Filippo Buccella, Annamaria De Luca, Miranda D. Grounds, on behalf of the 227th ENMC workshop study group November 16, 2017

• For the first time, the issue of improving translatability of preclinical results was discussed with a wide range of stakeholders representing the researchers‘ and the clinicians‘ communities, the journal editors, the funding bodies, the regulatory agencies, industry and patient representatives.• Challenges and pitfalls regarding the planning, funding, reporting and publishing of efficacy studies and confirmatory studies in animal models, the publishing of negative results and the sharing of data, were thoroughly discussed.… Read More...

Torsten Kraya, Marcus Deschauer, Pushpa Raj Joshi, Stephan Zierz, Charly Gaul November 15, 2017

Background

Mitochondrial diseases are a heterogeneous group of diseases with different phenotypes and genotypes. Headache and, particularly migraine, seems to occur often in patients with MELAS and in patients with CPEO phenotypes. The International Classification of Headache Disorders (ICHD-3 beta) has classified headache as a secondary entity only in MELAS patients.

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