Antonio García-Hermoso, Vicente Martínez-Vizcaíno, Manuel Ángel Gomez-Marcos, Iván Cavero-Redondo, José Ignacio Recio-Rodriguez, Luis García-Ortiz February 3, 2018

Studies concerning ideal cardiovascular (CV) health and its relationship with arterial stiffness are lacking. This study examined the association between arterial stiffness with ideal CV health as defined by the American Heart Association, across age groups and gender.

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Jiaqi Liao, Tao Hong, Jinxian Xu, Erming Zeng, Bin Tang, Wentao Lai February 3, 2018

Moyamoya disease has a high incidence of cerebral vascular accident in children and adolescents, which can endanger the physical and mental health of children and adults seriously. However, the etiology and the pathogenesis of moyamoya disease remain unclear. Connexin43 (Cx43) is a predominant intercellular gap junction protein that plays an important role in the normal function of arteries and the development of several cardiovascular diseases.… Read More...

admin February 3, 2018

Abstract

The most prevalent neurological disorders of myelin include perinatal brain injury leading to cerebral palsy in infants and multiple sclerosis in adults. Although these disorders have distinct etiologies, they share a common neuropathological feature of failed progenitor differentiation into myelin-producing oligodendrocytes and lack of myelin, for which there is an unmet clinical need.… Read More...

Andreas Eleftheriou, Avan Sabir Rashid, Fredrik Lundin February 3, 2018

Cerebrovascular events are a recognized complication of cardiac catheterization, with various neurological symptoms. The incidence is estimated to be .3%-.4%.1 A much more infrequent complication is a contrast-induced encephalopathy (CIE) described about 50 cases in the literature. The pathogenesis is believed to be a direct neurotoxic effect causing an osmotic disruption of the blood–brain barrier.2,3 Risk factors are hypertension, diabetes mellitus, renal impairment, large volumes of contrast, and previous adverse reaction to iodinated contrast.… Read More...

Narihide Shinoda, Masafumi Mori, Shogo Tamura, Kazuyoshi Korosue, Shigeru Kose, Eiji Kohmura February 3, 2018

Direct oral anticoagulant (DOAC) dose is adjusted according to manufacturer’s recommendations when introduced. However, subsequent changes from appropriate DOAC doses to “unintended” inappropriate low-dose DOAC (ILD) due to increased body weight (BW) or decreased serum creatinine concentration might be overlooked. We investigated outcomes in patients receiving appropriate DOAC, “intended” ILD, or unintended ILD, to determine the optimal review time for DOAC doses and associated factors.… Read More...

Mark Fisher, Kevin Kapur, Sylvia Soo, Yung Lyou, Steven S. Schreiber, Michael J. Kim February 3, 2018

Disseminated microinfarctions are uncommonly encountered in clinical practice. Here we describe a patient with long-standing cerebral microbleeds who developed acute cognitive decline in the setting of acute hypotension. Magnetic resonance imaging showed acute disseminated microinfarctions, with no change in microbleeds. This case emphasizes the important relationship between ischemic and hemorrhagic microvascular disease of the brain, especially in the setting of acute blood pressure changes compounding preexisting microvascular injury.… Read More...

Alexandra Filipov, Anne D. Ebert, Eva Neumaier-Probst, Angelika Alonso February 3, 2018

Intravenous thrombolysis with recombinant tissue plasminogen activator is still not approved by the European Medicines Agency for patients with diabetes mellitus and previous stroke. We assessed functional benefit and potential risk of thrombolysis in patients with diabetes and previous stroke and the influence of age, preexisting diabetic damage, as well as acute and chronic hyperglycemia on outcome, symptomatic intracranial hemorrhage, and in-hospital mortality.… Read More...

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