Kuperus, E., Kruijshaar, M. E., Wens, S. C. A., de Vries, J. M., Favejee, M. M., van der Meijden, J. C., Rizopoulos, D., Brusse, E., van Doorn, P. A., van der Ploeg, A. T., van der Beek, N. A. M. E. November 11, 2017

Objective:

To determine the effect of enzyme replacement therapy (ERT) after 5 years and to identify predictors for a favorable response because few data are available on the long-term efficacy of ERT in Pompe disease.

Methods:

We included 102 adult patients with Pompe disease in a nationwide, prospective cohort study.… Read More...

Kuperus, E., Kruijshaar, M. E., Wens, S. C. A., de Vries, J. M., Favejee, M. M., van der Meijden, J. C., Rizopoulos, D., Brusse, E., van Doorn, P. A., van der Ploeg, A. T., van der Beek, N. A. M. E. November 11, 2017

Objective:

To determine the effect of enzyme replacement therapy (ERT) after 5 years and to identify predictors for a favorable response because few data are available on the long-term efficacy of ERT in Pompe disease.

Methods:

We included 102 adult patients with Pompe disease in a nationwide, prospective cohort study.… Read More...

Jefferson, A. L., Liu, D., Gupta, D. K., Pechman, K. R., Watchmaker, J. M., Gordon, E. A., Rane, S., Bell, S. P., Mendes, L. A., Davis, L. T., Gifford, K. A., Hohman, T. J., Wang, T. J., Donahue, M. J. November 11, 2017

Objective:

To assess cross-sectionally whether lower cardiac index relates to lower resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults.

Methods:

Vanderbilt Memory & Aging Project participants free of stroke, dementia, and heart failure were studied (n = 314, age 73 ± 7 years, 59% male, 39% with mild cognitive impairment).… Read More...

Jefferson, A. L., Liu, D., Gupta, D. K., Pechman, K. R., Watchmaker, J. M., Gordon, E. A., Rane, S., Bell, S. P., Mendes, L. A., Davis, L. T., Gifford, K. A., Hohman, T. J., Wang, T. J., Donahue, M. J. November 11, 2017

Objective:

To assess cross-sectionally whether lower cardiac index relates to lower resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults.

Methods:

Vanderbilt Memory & Aging Project participants free of stroke, dementia, and heart failure were studied (n = 314, age 73 ± 7 years, 59% male, 39% with mild cognitive impairment).… Read More...

Jefferson, A. L., Liu, D., Gupta, D. K., Pechman, K. R., Watchmaker, J. M., Gordon, E. A., Rane, S., Bell, S. P., Mendes, L. A., Davis, L. T., Gifford, K. A., Hohman, T. J., Wang, T. J., Donahue, M. J. November 11, 2017

Objective:

To assess cross-sectionally whether lower cardiac index relates to lower resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults.

Methods:

Vanderbilt Memory & Aging Project participants free of stroke, dementia, and heart failure were studied (n = 314, age 73 ± 7 years, 59% male, 39% with mild cognitive impairment).… Read More...

Kowalec, K., McKay, K. A., Patten, S. B., Fisk, J. D., Evans, C., Tremlett, H., Marrie, R. A., For the CIHR Team in Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS) November 11, 2017

Objective:

To evaluate the association between comorbidity and relapse rate in individuals with multiple sclerosis (MS).

Methods:

We recruited individuals with prevalent relapsing-onset MS from 4 Canadian MS Clinics to participate in a 2-year prospective multicenter cohort study involving cross-sectional assessment of comorbidities and relapses.… Read More...

Kowalec, K., McKay, K. A., Patten, S. B., Fisk, J. D., Evans, C., Tremlett, H., Marrie, R. A., For the CIHR Team in Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS) November 11, 2017

Objective:

To evaluate the association between comorbidity and relapse rate in individuals with multiple sclerosis (MS).

Methods:

We recruited individuals with prevalent relapsing-onset MS from 4 Canadian MS Clinics to participate in a 2-year prospective multicenter cohort study involving cross-sectional assessment of comorbidities and relapses.… Read More...

Dodel, R. November 11, 2017

Recent evidence from histopathologic, CSF, and amyloid PET studies show that β-amyloid (Aβ) pathology is also involved in the pathophysiology of Parkinson disease (PD), correlating with a more rapid cognitive decline and predicting progression in levodopa-resistant gait impairment.1 The pathophysiology as well as the neural networks involved, however, are not fully understood, especially the intriguing interaction between α-synuclein and Aβ pathology.… Read More...

Dodel, R. November 11, 2017

Recent evidence from histopathologic, CSF, and amyloid PET studies show that β-amyloid (Aβ) pathology is also involved in the pathophysiology of Parkinson disease (PD), correlating with a more rapid cognitive decline and predicting progression in levodopa-resistant gait impairment.1 The pathophysiology as well as the neural networks involved, however, are not fully understood, especially the intriguing interaction between α-synuclein and Aβ pathology.… Read More...

Damush, T. M., Miech, E. J., Sico, J. J., Phipps, M. S., Arling, G., Ferguson, J., Austin, C., Myers, L., Baye, F., Luckhurst, C., Keating, A. B., Moran, E., Bravata, D. M. November 11, 2017

Objective:

To identify key barriers and facilitators to the delivery of guideline-based care of patients with TIA in the national Veterans Health Administration (VHA).

Methods:

We conducted a cross-sectional, observational study of 70 audiotaped interviews of multidisciplinary clinical staff involved in TIA care at 14 VHA hospitals.… Read More...

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