Christine Verboon, Heleen van Berghem, Pieter A. van Doorn, Liselotte Ruts, Bart C. Jacobs October 24, 2017

Abstract

Background

Patients with Miller Fisher syndrome (MFS) may have a relatively mild clinical course or progress to Guillain-Barré syndrome with limb weakness (MFS-GBS overlap syndrome). Other variants in this spectrum are GBS with ophthalmoparesis and Bickerstaff’s Brainstem encephalitis (BBE).

Aim

To compare the clinical course of MFS and overlap syndromes and to identify predictors of disease progression.

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Shauni Nuyts, Wendyl D'Souza, Stephen C. Bowden, Simon J. Vogrin October 24, 2017

Summary

According to the International League Against Epilepsy (ILAE) definition, no structural abnormalities are present on a standard brain magnetic resonance image in genetic generalized epilepsy (GGE) patients. However, recent studies raise contradictory evidence with increasing use of quantitative magnetic resonance imaging techniques.

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Daniel Weintraub, Lana M. Chahine, Keith A. Hawkins, Andrew Siderowf, Shirley Eberly, David Oakes, John Seibyl, Matthew B. Stern, Kenneth Marek, Danna Jennings, October 24, 2017

ABSTRACT

Background

Prospective data on cognition in prodromal Parkinson’s disease are limited. The objectives of this study were to assess in prodromal PD (1) if baseline cognition predicts conversion to clinical PD, (2) if baseline dopamine transporter binding predicts longitudinal changes in cognition, and (3) if impaired olfaction predicts future cognitive decline.

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Felix Fluri, Uwe Malzahn, György A. Homola, Michael K. Schuhmann, Christoph Kleinschnitz, Jens Volkmann October 24, 2017

Abstract

Objective: One-third of all stroke survivors are unable to walk, even after intensive physiotherapy. Thus, other concepts to restore walking are needed. Since electrical stimulation of the mesencephalic locomotor region (MLR) is known to elicit gait movements, this area might be a promising target for restorative neurostimulation in stroke patients with gait disability.

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Yi Gong, Nikhil Sasidharan, Fiza Laheji, Matthew Frosch, Patricia Musolino, Rudy Tanzi, Doo Yeon Kim, Alessandra Biffi, Joseph El Khoury, Florian Eichler October 24, 2017

Abstract

Objective: Mutations in ABCD1 cause the neurodegenerative disease adrenoleukodystrophy, which manifests as the spinal cord axonopathy adrenomyeloneuropathy (AMN) in nearly all males surviving into adulthood. Microglial dysfunction has long been implicated in pathogenesis of brain disease but its role in the spinal cord is unclear.

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Fred S. Sarfo, Dorcas Owusu, Sheila Adamu, Dominic Awuah, Lambert Appiah, Mansa Amamoo, Aloysius Loglo, Mayowa Owolabi, Bruce Ovbiagele October 24, 2017

Measurement of plasma molecular markers among stroke patients has been proposed as an avenue for improving the accuracy of stroke diagnosis. There is paucity of data on the potential role of these markers in resource-limited settings, where the burden of stroke is greatest.… Read More...

Anna Losurdo, Valerio Brunetti, Aldobrando Broccolini, Pietro Caliandro, Giovanni Frisullo, Roberta Morosetti, Fabio Pilato, Paolo Profice, Nadia Mariagrazia Giannantoni, Maria Luisa Sacchetti, Elisa Testani, Catello Vollono, Giacomo Della Marca October 24, 2017

Obstructive sleep apnea (OSA) and dysphagia are common in acute stroke and are both associated with increased risk of complications and worse prognosis. The aims of the present study were (1) to evaluate the prevalence of OSA and dysphagia in patients with acute, first-ever, ischemic stroke; (2) to investigate their clinical correlates; and (3) to verify if these conditions are associated in acute ischemic stroke.… Read More...

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