admin October 22, 2017

Abstract

Multiple system atrophy (MSA) is a rapidly progressing fatal synucleinopathy of the aging population characterized by parkinsonism, dysautonomia, and in some cases ataxia. Unlike other synucleinopathies, in this disorder the synaptic protein, α-synuclein (α-syn), predominantly accumulates in oligodendroglial cells (and to some extent in neurons), leading to maturation defects of oligodendrocytes, demyelination, and neurodegeneration.… Read More...

Yukie Kanai, Hiroaki Oguro, Nao Tahara, Hanako Matsuda, Hiroyuki Takayoshi, Shingo Mitaki, Keiichi Onoda, Shuhei Yamaguchi October 21, 2017

We investigated recurrent stroke volume with nonvalvular atrial fibrillation (NVAF) patients treated with non–vitamin K antagonist oral anticoagulants (NOACs) about clinical backgrounds and number of recurrent stroke.

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J. Rendu, C. Bosson, N. Roux-Buisson, A. Chatagnon, B. Bankole, F. Rivier, J. Durigneux, S. Monges, T. Stojkovic, N. Romero, I. Marty, J. Fauré October 21, 2017

In skeletal muscles, the ryanodine receptor of type 1 (RyR1) is the calcium channel by which calcium is released from the sarcoplasmic reticulum to the cytoplasm. This step leads to the contraction of the striated muscle fiber. Therefore, RyR1 is the corner stone of the excitation-contraction coupling.… Read More...

Michael H. Lawless October 21, 2017

Journal of Neurosurgery: Spine, Ahead of Print.
OBJECTIVEThis study was performed to determine whether decompression of penetrating spinal cord injury (SCI) due to explosive shrapnel leads to greater neurological recovery than conservative management.METHODSIn accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search using PubMed/MEDLINE, Web of Science, Google Scholar, and the Defense Technical Information Center public site was conducted on May 2, 2016.… Read More...

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