Michael A. Mooney September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVEThe objective of this study was to evaluate the feasibility of using confocal reflectance microscopy (CRM) ex vivo to differentiate adenoma from normal pituitary gland in surgical biopsy specimens. CRM allows for rapid, label-free evaluation of biopsy specimens with cellular resolution while avoiding some limitations of frozen section analysis.METHODSBiopsy specimens from 11 patients with suspected pituitary adenomas were transported directly to the pathology department.… Read More...

David S. Xu September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVESeizures are the most common presenting symptom of newly diagnosed WHO Grade II gliomas (low-grade glioma [LGG]) and significantly impair quality of life. Although gross-total resection of LGG is associated with better seizure control, it remains unclear whether an extent of resection (EOR) “threshold” exists for long-term seizure control.… Read More...

Adeel Ilyas September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVECyst formation can occasionally occur after stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVMs). Given the limited data regarding post-SRS cyst formation in patients with AVM, the time course, natural history, and management of this delayed complication are poorly defined.… Read More...

Luis E. Savastano September 5, 2017

Journal of Neurosurgery, Ahead of Print. Korsakoff syndrome is a chronic memory disorder caused by a severe deficiency of thiamine that is most commonly observed in alcoholics. However, some have proposed that focal structural lesions disrupting memory circuits—in particular, the mammillary bodies, the mammillothalamic tract, and the anterior thalamus—can give rise to this amnestic syndrome.… Read More...

Elham Rostami September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVEDelayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) is one of the major contributors to poor outcome. It is crucial to be able to detect early signs of DCI to prevent its occurrence. The objective of this study was to determine if low cerebral blood flow (CBF) measurements and pathological microdialysis parameters measured at the bedside can be observed early in patients with SAH who later developed DCI.METHODSThe authors included 30 patients with severe SAH.… Read More...

Daniel R. Cleary September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVESurgical simulation has the potential to supplement and enhance traditional resident training. However, the high cost of equipment and limited number of available scenarios have inhibited wider integration of simulation in neurosurgical education. In this study the authors provide initial validation of a novel, low-cost simulation platform that recreates the stress of surgery using a combination of hands-on, model-based, and computer elements.… Read More...

Sasidhar Venkata Manda September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVEHigh-grade glial brain tumors are often characterized by an elevated expression of the tumorigenic epidermal growth factor receptor variant III (EGFRvIII). The authors sought to establish a clinically adaptive protocol as a noninvasive diagnostic tool for EGFRvIII detection through serum exosomes.METHODSPurity of serum exosome/RNA was confirmed by electron microscopy and flow cytometry and through an RNA bioanalyzer profile.… Read More...

Radek Kolecki September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVEThe precise threshold differentiating normal and elevated intracranial pressure (ICP) is variable among individuals. In the context of several pathophysiological conditions, elevated ICP leads to abnormalities in global cerebral functioning and impacts the function of cranial nerves (CNs), either or both of which may contribute to ocular dysmotility.… Read More...

Hidetoshi Matsukawa September 5, 2017

Journal of Neurosurgery, Ahead of Print. OBJECTIVEAfter internal carotid artery (ICA) sacrifice without revascularization for complex aneurysms, ischemic complications can occur. In addition, hemodynamic alterations in the circle of Willis create conditions conducive to the formation of de novo aneurysms or the enlargement of existing untreated aneurysms.… Read More...

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