Ginsberg, L. October 6, 2017

Introduction

The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

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    Yu-Hsuan Chuang, Pei-Chen Lee, Tim Vlaar, Claire Mulot, Marie-Anne Loriot, Johnni Hansen, Christina M. Lill, Beate Ritz, Alexis Elbaz October 5, 2017

    ABSTRACT

    Objective: Inflammatory response plays an important role in Parkinson’s disease (PD). Previous studies have reported an association between human leukocyte antigen (HLA)-DRB1 and the risk of PD. There has also been growing interest in investigating whether inflammation-related genes interact with environmental factors such as smoking to influence PD risk.

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    Niklas Mattsson, Henrik Zetterberg, Niklas Nielsen, Kaj Blennow, Josef Dankiewicz, Hans Friberg, Gisela Lilja, Philip S. Insel, Christian Rylander, Pascal Stammet, Anders Aneman, Christian Hassager, Jesper Kjaergaard, Michael Kuiper, Tommaso Pellis, Jørn Wetterslev, Matthew Wise, Tobias Cronberg October 5, 2017

    Abstract

    Objective: To test serum tau as a predictor of neurological outcome after cardiac arrest.

    Methods: We measured the neuronal protein tau in serum at 24, 48, and 72 h after cardiac arrest in 689 patients in the prospective international Target Temperature Management trial.

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    Jonathan J. Halford, Michael R. Sperling, Dileep R. Nair, Dennis J. Dlugos, William O. Tatum, Jay Harvey, Jacqueline A. French, John R. Pollard, Edward Faught, Katherine H. Noe, Thomas R. Henry, Gina M. Jetter, Octavian V. Lie, Lola C. Morgan, Michael R. Girouard, Damon P. Cardenas, Luke E. Whitmire, Jose E. Cavazos October 5, 2017

    Summary

    Objective

    A prospective multicenter phase III trial was undertaken to evaluate the performance and tolerability in the epilepsy monitoring unit (EMU) of an investigational wearable surface electromyographic (sEMG) monitoring system for the detection of generalized tonic–clonic seizures (GTCSs).

    Methods

    One hundred ninety-nine patients with a history of GTCSs who were admitted to the EMU in 11 level IV epilepsy centers for clinically indicated video-electroencephalographic monitoring also received sEMG monitoring with a wearable device that was worn on the arm over the biceps muscle.

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