Kiran Prakash October 24, 2018

I read with great interest the original article by Macedo-Campos et al1 titled “Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study.” Authors have explored the cerebrovascular reactivity assessed by breath-holding index (BHI) in the children with sickle cell disease (SCD). They have reported the impaired cerebrovascular reactivity in the children with SCD as compared to that of control subjects. However, few potential methodological limitations need to be addressed regarding this study.

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