Wang et al1 recently published a meta-analysis on the role of miR-146a polymorphism (rs11614913 T > C) and susceptibility to ischemic stroke and coronary artery disease (CAD) in Asian population and concluded that the recalled variant “may contribute to CAD susceptibility.” They showed the result related to the protective effect of CAD in homozygote model (CC versus TT, OR = .43, 95%CI = .39-.47, P < .00001), as their most significant result, and indicated that “carrying CC homozygote genotype may play a protective role in development of disease.” While other results of their meta-analysis increased the risk of disease or had no significant effect (Fig 3 in Wang1 meta-analysis).

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